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Category: News

Not just Alagilla syndrome. Syndromic insufficiency of the interlobular bile ducts, secondary to HNF1β deficiency: a case history and review of the literature.


BACKGROUND: The lack of interlobular bile ducts is an important observation in liver biopsy in the diagnosis of cholestasis in newborns. So far, in addition to Alagilla syndrome, the syndromic insufficiency of the interlobular bile ducts has been documented in four cholestatic newborns with HFN1β mutations. A syndromic phenotype, known as renal cysts and diabetic syndrome (RCAD), has been identified. It is usually...Читать далее »

FODMAP tolerance — dietary reduction in irritable bowel syndrome — effectiveness, adherence and body weight course


BACKGROUND: The reduced FODMAP diet (fermentable oligo-, di-, monosaccharides and polyols) is one of the established strategies for the treatment of irritable bowel syndrome (IBS). However, the disadvantages of this diet are significant and can lead to weight loss and inadequate patient adherence. Reports from Germany are not yet available. MATERIAL AND METHODS: In a prospective study, 93 patients with IBS were examined in accordance with rum III....Читать далее »

Gas, bloating and belching: an approach to assessment and control


Gas, bloating and belching associated with various conditions, but most often they are caused by functional gastrointestinal disorders. These disorders are characterized by impaired motility and visceral hypersensitivity, which are often aggravated by psychological stress. An organized approach to the assessment of symptoms contributes to the establishment of a trusted therapeutic relationship. Patients can be reliably diagnosed without...Читать далее »

Coupled dynamics of intestinal microbiome and immune system-A mathematical study


An immune system sometimes causes an exaggerated response to harmless materials, such as pollens, eggs, and metals, which is known as an allergy. The regulatory T (Treg) cells suppress such allergic responses. Recently, it has been observed that intestinal microbiota have a close association with immune systems. For example, some strains of bacteria induce Treg cells by producing short-chain fatty acids, such as butyrate. Moreover,...Читать далее »

[Importance of functional diagnostics in gastroenterology]


In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test can be carried out when there is a suspicion...Читать далее »

AGA Clinical Practice Update on Functional Gastrointestinal Symptoms in Patients With Inflammatory Bowel Disease: Expert Review


DESCRIPTION: The purpose of this clinical practice update review is to describe key principles in the diagnosis and management of functional gastrointestinal (GI) symptoms in patients with inflammatory bowel disease (IBD). METHODS: The evidence and best practices summarized in this manuscript are based on relevant scientific publications, systematic reviews, and expert opinion where applicable. Best practice advice 1: A stepwise approach...Читать далее »

Crocin as a novel therapeutic agent against colitis


Ulcerative colitis is a chronic inflammatory bowel disease with high incidence and prevalence worldwide. To investigate the therapeutic potency of crocin, as a pharmacologically active component of saffron, in dextran sodium sulfate (DSS)-induced colitis mice model. Experimental colitis was induced by 7-day administration of DSS dissolved in water at a concentration of 1.5% (w/v). The animals were randomly divided into four...Читать далее »

Food allergy: what it is and what it is not?


PURPOSE OF REVIEW: Food allergy is defined as an adverse health effect arising from a specific immune response that occurs reproducibly on exposure to a given food. Food intolerance, certain gastrointestinal or systemic diseases are often confused with or mislabeled as food allergy because of symptomatic similarity and general improvement from food avoidance. The differences between these diseases are crucial. RECENT FINDINGS: Compared...Читать далее »

Diagnosis and management of pancreatic exocrine insufficiency


In 2015, the Australasian Pancreatic Club (APC) published the Australasian guidelines for the management of pancreatic exocrineinsufficiency (http://pancreas.org.au/2016/01/pancreatic-exocrine-insufficiency-guidelines). Pancreatic exocrine insufficiency (PEI) occurs when normal digestion cannot be sustained due to insufficient pancreatic digestive enzyme activity. This may be related to a breakdown, at any point, in the pancreatic digestive chain:...Читать далее »

Eosinophilic colitis: Case series and literature review


INTRODUCTION: Primary eosinophilic colitis (EC) in adults is a rare and poorly studied disease, with 3 case series, 2 database-based studies and 52 case reports published to date. METHODS: Retrospective study of all adult EC cases diagnosed in a large tertiary hospital (Hospital Clínico San Carlos, Madrid) between 2006 and 2016. We included all cases with a histopathological diagnosis of EC and we selected only those cases that were...Читать далее »

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